Dr. rer. nat. Jerome Jatzlau
Jerome studied Biology at the Freie Universität Berlin with a focus on molecular and cellular biology from 2009 until 2014. He received the degree Master of Science with excellence in September of 2014. Since December 2014 Jerome is a member of the Knaus lab. In his research Jerome focuses on the visualization and characterization of BMP/TGFβ receptor complexes in the context of vascular biology. During his PhD, he described the function of a vascular bed specific BMP/ TGFβ receptor, UNC5B. Further he is interested in BMP receptor mutations that drive mechano-context dependent vascular malformations such as Pulmonary Arterial Hypertension. At the end of 2019 Jerome completed his PhD honored with “summa cum laude”.
Within the SFB1444 “Directed Cellular Self-Organisation for Advancing Bone Regeneration” he currently works together with the group of Prof. Stefan Mundlos at the Max Planck Institute for Molecular Genetics to study the effects of mechanical stimulation on vascular chromatin conformation and gene expression. Also he aims to further push the capabilities of BMP/TGFβ receptor visualization using super resolution microscopy techniques such as STED.
Jerome is part of the team teaching lipid and membrane biochemistry for Bachelor students at the Biochemistry department of FU Berlin and signaling for Doctoral candidates at (BSRT) Berlin-Brandenburg School for Regenerative Therapies (BSRT, DFG Graduate School 203).
Biochemistry
Researcher
Signal Transduction
Biochemisches Blockpraktikum- Lipide und Membranen
Method Module: Growth Factor Signaling and Interplay with Cell Mechanics
Melo, U. S., Jatzlau, J., Prada-Medina, C. A., Flex, E., Hartmann, S., Ali, S., Schöpflin, R., Bernardini, L., Ciolfi, A., Moeinzadeh, M. H., Klever, M.-K., Altay, A., Vallecillo-García, P., Carpentieri, G., Delledonne, M., Ort, M.-J., Schwestka, M., Ferrero, G. B., Tartaglia, M., Brusco, A., Gossen, M., Strunk, D., Geißler, S., Mundlos, S., Stricker, S., Knaus, P., Giorgio, E., & Spielmann, M. (2023). Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation. Nat Commun, 14(1), 2034. DOI:10.1038/s41467-023-37585-8
Quist-Løkken, I., Andersson-Rusch, C., Kastnes, M.H., Kolos, J.M., Jatzlau, J., Hella, H., Olsen, O.E., Sundan, A., Knaus, P., Hausch, F., Holien, T. FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells. Cell Commun Signal 21, 25 (2023). DOI: 10.1186/s12964-022-01033-9
Jatzlau J, Burdzinski W, Trumpp M, Obendorf L, Roßmann K, Ravn K, Hyvönen M, Bottanelli F, Broichhagen J, Knaus P. A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding. Commun Biol. 2023 Jan 12. DOI: 10.1038/s42003-022-04388-4
Mendez, P.L.; Obendorf, L.; Jatzlau, J.; Burdzinski, W.; Reichenbach, M.; Nageswaran, V.; Haghikia, A.; Stangl, V.; Hiepen, C.; Knaus, P.; Atheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes. BMC Biol. 2022 Sep 28;20(1):210. doi: 10.1186/s12915-022-01396-y.
Kolos, J.M., Pomplun S., Jung S., Rieß B., Purder P.L., Voll A.M., Merz S., Gnatzy M., Geiger T.M., Quist-Løkken I., Jatzlau J., Knaus P., Holien T., Bracher A., Meyners C., Czodrowski P., Krewald V., Hausch F. Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chem. Sci., 2021,12, 14758-14765, doi: 10.1039/d1sc04638a
Reichenbach, M.; Mendez, P.-L.; da Silva Madaleno, C.; Ugorets, V.; Rikeit, P.; Boerno, S.; Jatzlau, J.; Knaus, P. Differential Impact of Fluid Shear Stress and YAP/TAZ on BMP/TGF‐β Induced Osteogenic Target Genes. Advanced Biology (2021). https://doi.org/10.1002/adbi.202000051
da Silva Madaleno, C., Jatzlau, J. and Knaus, P. (2020). BMP signalling in a mechanical context - Implications for bone biology. Bone: doi.org/10.1016/j.bone.2020.115416
Hiepen C., Jatzlau J., Knaus P. (2020). Biomechanical stress provides a second hit in the establishment of BMP/TGFβ-related vascular disorders. Cell Stress 2020, Jan 20;4(2):44-47. doi: 10.15698/cst2020.02.213.
Brunner P, Hastar N, Kaehler C, Burdzinski W, Jatzlau J, Knaus P. AMOT130 drives BMP-SMAD signaling at the apical membrane in polarized cells. Mol Biol Cell. 2019 Dec 4. doi: 10.1091/mbc.E19-03-0179
Hiepen C, Jatzlau J, Hildebrandt S, Kampfrath B, Goktas M, Murgai A, Camacho JLC, Haag R, Ruppert C, Sengle G, Cavalcanti-Adam EA, Blank KG, Knaus P. BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics PLoS Biol. 2019 Dec 11. doi: 10.1371/journal.pbio.3000557
Dörpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi MP, Heroven C, Schreiber I, Wendel G, Ruschke K, Stricker S, Knaus P. IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation. Sci Rep. 2017 Dec 8;7(1):17192. doi: 10.1038/s41598-017-17595-5.