Publikationen
Prof. Dr. Timo Niedermeyer:
(2023)
Schwark, M., Martínez Yerena, J.A., Röhrborn, K., Hrouzek, P., Divoká, P., Štenclová, L., Delawská, K., Enke, H., Vorreiter, C., Wiley, F., Sippl, W., Sobotka, R., Saha, S., Wilde, S.B., Mareš, J., Niedermeyer, T.H.J. (shared first and shared senior authorship. 2023. More than just an Eagle Killer: The freshwater cyanobacterium Aetokthonos hydrillicola produces highly toxic dolastatin derivatives. accepted.
Štenclová, L. Wilde, S.B., Schwark, M., Cullen, J.L., McWhorter, S.A., Niedermeyer, T.H.J., Henderson, W.M., Mareš, J. 2023. Occurrence of aetokthonotoxin producer in natural samples – a PCR protocol for easy detection. Harmful Algae, 125: 102425
(2021)
Breinlinger, S., Phillips, T.J., Haram, B.N., Mareš, J., Martínez Yerena, J.A., Hrouzek, P., Sobotka, R., Henderson, W.M., Schmieder, P., Williams, S.M., Lauderdale, J.D., Wilde, H.D., Gerrin, W., Kust, A., Washington, J.W., Wagner, C., Geier, B., Liebeke, M., Enke, H., Niedermeyer, T.H.J., Wilde, S.B. (shared first and shared senior authorship). 2021. Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy. Science, 6536: eaax9050
Ricardo, M.G., Schwark, M., Llanes, D., Niedermeyer, T.H.J., Westermann, B. 2021. Total Synthesis of Aetokthonotoxin, the Cyanobacterial Neurotoxin Causing Vacuolar Myelinopathy. Chem. Eur. J., 27: 12032-12035.
Ortlieb, N., Klenk, E., Kulik, A., Niedermeyer, T.H.J. 2021. Development of an agar-plug cultivation system for bioactivity assays of actinomycete strain collections. PLOS ONE, 16: e0258934 .
Mfotie Njoya, E., Fewou Moundipa, P., Niedermeyer, T.H.J. 2021. Codiaeum variegatum (L.) Rumph. ex A. Juss. (Euphorbiaceae): An overview of its botanical diversity, traditional uses, phytochemistry, pharmacological effects and perspectives towards developing its plant-based products. J Ethnopharmacol, 277: 114244 .
Kirchner, N., Cano-Prieto, C., Schulz-Fincke, A., Gütschow, M, Ortlieb, N., Moschny, J., Niedermeyer, T.H.J., Horak, J., Lämmerhofer, M, Van der Voort, M, Raaijmakers, J. , Gross, H. 2021. Discovery of Thanafactin A, a Linear Proline-Containing Octa-Lipopeptide from Pseudomonas sp. SH-C52, Motivated by Genome Mining. J Nat Prod, 84: 101–109 .
Wex, K.W.; Saur, J.S.; Handel, F.; Ortlieb, N.; Kulik, A.; Mokeev, V.; Niedermeyer, T.H.J.; Mast, Y.; Grond, S.; Berscheid, A; Brötz-Oesterhelt, H. 2021. Bioreporters for direct mode of action-informed screening of antibiotic producer strains. Cell Chem Biol, 28: 1242-1252.e4 .
(2020)
Chilczuk, T., Monson, R., Schmieder, P., Christov, V., Enke, H., Salmond, G., Niedermeyer, T.H.J. 2020. Ambigols from the Cyanobacterium Fischerella ambigua increase Prodigiosin Production in Serratia spp. ACS Chem Biol, 15: 2929-2936.
Moschny, J., Lorenzen, W., Hilfer, A., Eckenstaler, R., Jahns, S., Enke, H., Enke, D., Schneider, P., Benndorf, R., Niedermeyer, T.H.J. 2020. Precursor-Directed Biosynthesis and Fluorescence Labeling of Clickable Microcystins. J Nat Prod, 83: 1960-1970 .
Chilczuk, T., Schäberle, T.F., Vahdati, S., Mettal, U., El Omari, M., Enke, H., Wiese, M., König, G.M., Niedermeyer, T.H.J. 2020. Halogenation-guided chemical screening provides insight into tjipanazole biosynthesis by the cyanobacterium Fischerella ambigua. ChemBioChem, 21: 2170 –2177 .
Chilczuk, T., Steinborn, C., Breinlinger, S., Zimmermann-Klemd, A.M., Huber, R., Enke, H., Enke, D., Niedermeyer, T.H.J., Gründemann, C. 2020. Hapalindoles from the Cyanobacterium Hapalosiphon sp. Inhibit T Cell Proliferation. Planta Med 2020, 86: 96- 103 .
Kossack, R., Breinlinger, S., Nguyen, T.; Moschny, J.; Straetener, J.; Berscheid, A.; Brötz-Oesterhelt, H.; Enke, H.; Schirmeister, T.; Niedermeyer, T.H.J. 2020. Nostotrebin 6 Related Cyclopentenediones and δ-Lactones with Broad Activity Spectrum Isolated from the Cultivation Medium of the Cyanobacterium Nostoc sp. CBT1153. J Nat Prod, 83: 392-400 .
(2019)
Buchmann, A., Cano-Prieto, C., Nafis, A., Barakate, M., Baz, M., Hassani, L., Ortlieb, N., Niedermeyer, T.H.J., Gross, H. 2019. Draft Genome Sequence of the Novonestmycin-Producing Strain Streptomyces sp. Z26, isolated from potato rhizosphere in Morocco. Microbiol Ressour Announc, 8:e01514-
(2018)
Ortlieb, N., Bretzel, K., Kulik, A., Haas, J., Lüdeke, S., Keilhofer, N., Schrey, S. D., Gross, H., Niedermeyer, T.H.J. 2018. Xanthocidin derivatives from the endophytic Streptomyces sp. AcE210 provide insight into the xanthocidin biosynthesis. ChemBioChem, 19:2472-2480.
Ortlieb, N., Keilhofer, N., Schrey, S.D., Gross, H., Niedermeyer, T.H.J. 2018. Draft Genome Sequence of the Xanthocidin-Producing Strain Streptomyces sp. AcE210, isolated from a root nodule of Alnus glutinosa (L.). Microbiol Ressour Announc, 7:e01190-18.
Spohn, M., Edenhart, S., Alanjary, M., Ziemert, N., Wibberg, D., Kalinowski, J., Niedermeyer, T.H.J., Stegmann, E., Wohlleben, W. 2018. Identification of a novel aminopolycarboxylic acid siderophore gene cluster encoding the biosynthesis of ethylenediaminesuccinic acid hydroxyarginine (EDHA). Metallomics, 10: 722-734.
(2017)
Merdivan, S., Jenett-Siems, K., Siems, K., Niedermeyer, T.H.J., Schultze N., Steinborn C., Gründemann C., Lindequist, U. 2017. Effects of extracts and compounds from Tricholoma populinum Lange on degranulation, IL-2 and IL-8 secretion of immune cells. Z Naturforsch C, 72(7-8)c: 277-283.
Merdivan, S., Jenett-Siems, K., Siems, K., Niedermeyer, T.H.J., Solis M.J., Unterseher, M., Lindequist, U. 2016. Inhibition of degranulation of RBL-2H3 cells by extracts and compounds from Armillaria ostoyae. Planta Med Int Open, 4(1): e1-e7.
(2016)
Schreuder, H., Liesum, A., Lönze, P., Stump, H., Hoffmann, H., Schiell, M., Kurz, M., Toti, L., Bauer, A., Kallus, C., Klemke-Jahn, C., Czech, J., Kramer, D., Enke, H., Niedermeyer, T., Morrison, V., Kumar, V., Brönstrup, M. 2016. Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa). Sci Reports, srep32958.
Preisitsch, M., Niedermeyer, T.H.J., Heiden, S.E., Neidhardt, I., Kumpfmüller, J., Wurster, M., Harmrolfs, K., Wiesner, C., Enke, H., Müller, R., Mundt, S. 2016. Cylindrofridins A–C, Linear Cylindrocyclophane-Related Alkylresorcinols from the Cyanobacterium Cylindrospermum stagnale. J Nat Prod 79: 106-115.
Preisitsch, M., Heiden, S.E., Beerbaum, M., Niedermeyer, T.H.J., Schneefeld, M., Herrmann, J., Kumpfmüller, J., Thürmer, A., Neidhardt, I., Wiesner, C., Daniel, R., Müller, R., Bange, F.C., Schmieder, P., Schweder, T., Mundt, S. 2016. Effects of Halide Ions on the Carbamidocyclophane Biosynthesis in Nostoc sp. CAVN2. marine drugs 14(1): 21.
Iftime, D., Kulik, A., Härtner, T., Rohrer, S., Niedermeyer, T.J.H., Stegmann, E., Weber, T., Wohlleben, W. 2015. Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365. J Ind Microbiol Biotechnol 43: 277-291.
(2015)
Niedermeyer, T.H.J. 2015. Anti-infective Natural Products from Cyanobacteria. Planta Med 81: 1309-1325.
Bäcker, C., Jenett-Siems, K., Siems, K., Niedermeyer, T.H.J., Wurster, M., Bodtke, A.,Lindequist, U. 2015. Taraxastane-Type Triterpene Saponins isolated from Pittosporum angustifolium Lodd. Z Naturforsch B 70: 403-408.
Preisitsch, M., Harmrolfs, K., Pham, H., Heiden, S., Füssel, A., Wiesner, C., Pretsch, A., Swiatecka-Hagenbruch, M., Niedermeyer, T.H.J., Müller, R., Mundt, S. 2015. Anti-MRSA acting Carbamidocyclophanes H − L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. J Antibiot 68: 165-177.
(2014)
Bäcker, C., Jenett-Siems, K., Siems, K., Wurster, M., Bodtke, A., Niedermeyer, T.H.J., Lindequist, U. 2014. Novel mono- and bisdesmosidic triterpene glycosides from Pittosporum angustifolium Lodd. Z Naturforsch B 69b: 1026–1044.
Niedermeyer, T.H.J., Daily, A., Swiatecka-Hagenbruch, M., Moscow, J.A. 2014. Selectivity and Potency of Microcystin Congeners against OATP1B1 and OATP1B3 Expressing Cancer Cells. PLoS One 9: e91476.
Niedermeyer, T.H.J., Kurmayer, R., Schmieder, P. 2014. Isolation of microcystins from the cyanobacterium Planktothrix rubescens strain No80. Nat Products Bioprospect 4: 37–45.
(2013)
Niedermeyer, T.H.J., Jira, T., Lalk, M., Lindequist, U. 2013. Isolation of farnesylhydroquinones from the basidiomycete Ganoderma pfeifferi. Nat Products Bioprospect 3: 137–140.
(2012)
Niedermeyer, T.H.J., Strohalm, M. 2012. mMass as a software tool for the annotation of cyclic peptide tandem mass spectra. PLoS One 7: e44913.
"Publikationslücke" durch Tätigkeit in der Industrie (12/2004 - 10/2013)
(2007)
Niedermeyer, T.H.J., Lalk, M. 2007. Nuclear amination catalyzed by fungal laccases: Comparison of laccase catalyzed amination with known chemical routes to aminoquinones. J Mol Catal B Enzym 45: 113–117.
Mikolasch, A., Niedermeyer, T.H.J., Lalk, M., Witt, S., Seefeldt, S., Witt, S., Hammer, E., Schauer, F., Gesell, M., Ossig, S., Jülich, W.-D., Lindequist, U. 2007. Novel cephalosporins synthesized by amination of 2,5-dihydroxybenzoic acid derivatives using fungal laccases. Chem Pharm Bull 55: 412–416.
(2006)
Mikolasch, A., Niedermeyer, T.H.J., Lalk, M., Witt, S., Seefeldt, S., Witt, S., Hammer, E., Schauer, F., Gesell, M., Ossig, S., Jülich, W.-D., Lindequist, U. 2007. Novel penicillins synthesized by biotransformation using laccase from Trametes spec. Chem Pharm Bull 54: 632–638.
Poeckel, D.*, Niedermeyer, T.H.J.*, Pham, H.T.L., Mikolasch, A., Mundt, S., Lindequist, U., Lalk, M., Werz, O. 2006. Inhibition of Human 5-Lipoxygenase and Anti-Neoplastic Effects by 2-Amino-1,4-Benzoquinones. Med Chem 2: 591–595. (*equal contributions)
(2005)
Niedermeyer, T.H.J., Lindequist, U., Mentel, R., Gördes, D., Schmidt, E., Thurow, K., Lalk, M. 2005. Antiviral Terpenoid Constituents of Ganoderma pfeifferi. J Nat Prod 68 : 1728–1731.
Lindequist, U., Niedermeyer, T.H.J., Jülich, W.-D. 2005. The pharmacological potential of mushrooms. Evidence-based Complement Altern Med 2: 285–299.
Niedermeyer, T.H.J., Mikolasch, A., Lalk, M. 2005. Nuclear amination catalyzed by fungal laccases: reaction products of p-hydroquinones and primary aromatic amines. J Org Chem 70 : 2002–2008.
Manda, K., Hammer, E., Mikolasch, A., Niedermeyer, T., Dec, J., Jones, A.D., Benesi, A.J., Schauer, F., Bollag, J.-M. 2005. Laccase-induced cross-coupling of 4-aminobenzoic acid with para-dihydroxylated compounds 2,5-dihydroxy-N-(2-hydroxyethyl)-benzamide and 2,5-dihydroxybenzoic acid methyl ester. J Mol Catal B Enzym 35 : 86–92.
Buchbeiträge
Niedermeyer, T.H.J. 2016. Annotating and interpreting linear and cyclic peptide tandem mass spectra. In: Nonribosomal Peptide Synthesis: Methods and Protocols, Ed. B. Evans. Springer. Methods Mol Biol 1401: 1999- 207.
Niedermeyer, T.H.J., Kuchmina, E., Wilde, A. 2013. Engineering Cyanobacteria for Industrial Products. In: Cyanobacteria: An Economic Perspective, Ed. Sharma, N.K., Rai, A.K., Stal, L.J. John Wiley & Sons. pp. 303-318.
Niedermeyer, T., Brönstrup, M. 2012. Natural-product drug discovery from microalgae. In: Microalgal Biotechnology: Integration and Economy, Ed. Posten, C., Walter, C. de Gruyter. pp. 169–200.
Lehrbuch
E. Teuscher, U. Lindequist, M. Melzig, unter Mitarbeit von E. Lang, T. Niedermeyer und A. Weng. 2020 Biogene Arzneimittel, 8. Auflage. DAV
Insgesamt 42 Publikationen:
Erstautor von 12 Publikationen, Zweitautor von 4 Publikationen, Senior- und/oder korrespondierender Autor von 18 Publikationen
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Populärwissenschaftliche Beiträge
Breinlinger, S., Niedermeyer, T.H.J. 2021. Jagd auf den Adlermörder — Entdeckung eines neuen Cyanotoxins. BIOspektrum 27: 594–597 . Cover image contributed by us.
Niedermeyer, T.H.J. 2014. Biologisch aktive Naturstoffe aus Cyanobakterien der Gattung Nostoc. BIOspektrum 20: 151–15 . Cover image contributed by us.
Patente
Niedermeyer, T.H.J., Enke, H., Enke, D., Schuster, S. 2023. Organic Cytotoxin Oligomers and Uses Thereof as a Payload in Antibody-Drug Conjugates. Patent Application EP23187008.0
Niedermeyer, T.H.J., Enke, H., Enke, D., Stock, L., Schuster, S. 2022. A Method of Modifying an Organic Cytotoxin for use as Payload in an Antibody-Drug Conjugate and Modified Organic Cytotoxins Derived therefrom. Patent Application EP22192517.0
Niedermeyer, T.H.J., Enke, H., Kramer, D., Moschny, J., Lorenzen, W., Jahns, S. 2017. Method for Modifying Microcystins and Nodularins. PCT/EP2018/062156
Niedermeyer, T.H.J., Enke, H., Kramer, D., Moschny, J., Lorenzen, W., Jahns, S. 2017. Modified Microcystins and Nodularins. PCT/EP2018/062129
Dr. rer. nat. Alexander Weng:
(2022)
Schlaak L., Weise C., Kuropka B., Weng A. (2022) Sapovaccarin-S1 and -S2, Two Type I RIP Isoforms from the seeds of Saponaria vaccaria L., Toxins, 14 (7), 449.
Panjideh H., Niesler N., Weng A., Fuchs H. (2022) Improved therapy of B cell non-Hodgkin lymphoma by obinutuzumab-dianthin conjugates in combination with the endosomal escape enhancer SO1861, Toxins 14(7), 478.
Sonntag A., Mitdank H., Weng, A. (2022) Construction of Minicircle Suicide Genes Coding for Ribosome-Inactivating Proteins, Methods in Molecular Biology, Methods Mol Biol. 2521:157-171.
Mitdank, H., Tröger, M., Sonntag, A., Amini Shirazi, N., Woith, E., Fuchs, H., Kobelt, D., Walther, W., Weng, A. (2022) Suicide nanoplasmids coding for ribosome-inactivating proteins, Eur J Pharm Sci. 170, 106107.
(2021)
Mitdank, H., Sama, S., Tröger, M., Testa, MF., Ferrarese, D., Balestra, D., Pinotti, M., Weng, A. (2021) An advanced method for the small-scale production of high quality minicircle-DNA, Int J Pharm. 605, 120830.
Woith, E., Guerriero, G., Hausman, JF., Renaut J., Leclercq, C., Weng, A., & Melzig, MF. (2021) Potential, properties and sources of plant derived extracellular vesicles and nanovesicles, Int J Mol Sci. 22(7), 3719.
(2020)
Clochard, J., Jerz, G., Schmieder, P., Mitdank, H., Troger, M., Sama, S. & Weng, A. (2020) A new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance, Int J Pharm. 589, 119822.
Weise, C., Schrot, A., Wuerger, L. T. D., Adolf, J., Gilabert-Oriol, R., Sama, S., Melzig, M. F. & Weng, A. (2020) An unusual type I ribosome-inactivating protein from Agrostemma githago L, Sci Rep. 10, 15377.
(2019)
Kokorin, A., Weise, C., Sama, S., Weng, A. (2019) A new type 1 ribosome-inactivating protein from the seeds of Gypsophila elegans M.Bieb. Phytochemistry. 157:121-127.
Sama S., Jerz G., Thakur M., Melzig MF. & Weng A. (2019) Structure-Activity Relationship of Transfection-Modulating Saponins - A Pursuit for the Optimal Gene Trafficker. Planta Med. (Epub ahead of print, doi: 10.1055/a-0863-4795)
(2018)
Sama, S., Jerz G., Schmieder, P., Joseph, JF., Melzig, MF., Weng, A. (2018) Plant derived triterpenes from Gypsophila elegans M.Bieb. enable non-toxic delivery of gene loaded nanoplexes. J Biotechnol. 284:131-139.
Sama, S., Woith, E., Walther, W., Jerz, G., Chen, W., Hart, S., Melzig, MF., Weng, A. (2018) Targeted suicide gene transfections reveal promising results in nu/nu mice with aggressive neuroblastoma, Journal of controlled release, accepted manuscript.
Weng, A. (2017) A novel adenine-releasing assay for ribosome-inactivating proteins. J Chromatogr B Analyt Technol Biomed Life Sci. 1072:300-304.
(2017)
Sama, S., Jerz, G., Schmieder, P., Woith, E., Melzig, MF., Weng, A. (2017) Sapofectosid - Ensuring non-toxic and effective DNA and RNA delivery. Int J Pharm. 534(1-2):195-205.
Bhargava, C., Dürkop, H., Zhao, X., Weng, A., Melzig MF., Fuchs, H. (2017) Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861. Mol Oncol. 11(11):1527-1543.
Fuchs, H., Niesler, N., Trautner, A., Sama, S., Jerz, G., Panjideh, H., Weng, A. (2017) Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies. Biomedicines. 29;5(2).
Gilabert-Oriol, R., Furness, SGB., Stringer, BW., Weng, A., Fuchs, H., Day, BW., Kourakis, A., Boyd, AW., Hare, DL., Thakur, M., Johns, TG., Wookey, PJ. (2017) Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunol Immunother. 66(9):1217-1228.
(2016)
Gilabert-Oriol, R., Thakur, M., Haussmann, K., Niesler, N., Bhargava, C., Gorick, C., Fuchs, H. & Weng, A. (2016) Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin, Planta medica. 82(18), 1525-1531.
Fuchs, H., Weng, A. & Gilabert-Oriol, R. (2016) Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers, Toxins. 8(7).
Xie, W., Weng, A. & Melzig, M. F. (2016) MicroRNAs as New Bioactive Components in Medicinal Plants, Planta medica. 82(13), 1153-1162.
(2015)
Weng, A., Manunta, M. D., Thakur, M., Gilabert-Oriol, R., Tagalakis, A. D., Eddaoudi, A., Munye, M. M., Vink, C. A., Wiesner, B., Eichhorst, J., Melzig, M. F. & Hart, S. L. (2015) Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides, Journal of controlled release : official journal of the Controlled Release Society. 206, 75-90.
Schrot, J., Weng, A. & Melzig, M. F. (2015) Ribosome-inactivating and related proteins, Toxins. 7, 1556-615.
Holmes, S. E., Bachran, C., Fuchs, H., Weng, A., Melzig, M. F., Flavell, S. U. & Flavell, D. J. (2015) Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent, Immunopharmacology and immunotoxicology. 37, 42-55.
Gilabert-Oriol, R., Weng, A., von Mallinckrodt, B., Stoshel, A., Nissi, L., Melzig, M. F., Fuchs, H. & Thakur, M. (2015) Electrophoretic mobility as a tool to separate immune adjuvant saponins from Quillaja saponaria Molina, International journal of pharmaceutics. 487, 39-48.
Gilabert-Oriol, R., Weng, A., Trautner, A., Weise, C., Schmid, D., Bhargava, C., Niesler, N., Wookey, P. J., Fuchs, H. & Thakur, M. (2015) Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861, Biochemical pharmacology. 97, 247-55.
(2014)
von Mallinckrodt, B., Thakur, M., Weng, A., Gilabert-Oriol, R., Durkop, H., Brenner, W., Lukas, M., Beindorff, N., Melzig, M. F. & Fuchs, H. (2014) Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma, Future oncology. 10, 2161-75.
Thakur, M., Jerz, G., Tuwalska, D., Gilabert-Oriol, R., Wybraniec, S., Winterhalter, P., Fuchs, H. & Weng, A. (2014) High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins, Journal of chromatography B, Analytical technologies in the biomedical and life sciences. 955-956, 1-9.
Gilabert-Oriol, R., Weng, A., Mallinckrodt, B., Melzig, M. F., Fuchs, H. & Thakur, M. (2014) Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy, Current pharmaceutical design. 20, 6584-643.
Gilabert-Oriol, R., Thakur, M., von Mallinckrodt, B., Bhargava, C., Wiesner, B., Eichhorst, J., Melzig, M. F., Fuchs, H. & Weng, A. (2014) Reporter assay for endo/lysosomal escape of toxin-based therapeutics, Toxins. 6, 1644-66.
(2013)
Thakur, M., Weng, A., Pieper, A., Mergel, K., von Mallinckrodt, B., Gilabert-Oriol, R., Gorick, C., Wiesner, B., Eichhorst, J., Melzig, M. F. & Fuchs, H. (2013) Macromolecular interactions of triterpenoids and targeted toxins: role of saponins charge, International journal of biological macromolecules. 61, 285-94.
Thakur, M., Mergel, K., Weng, A., von Mallinckrodt, B., Gilabert-Oriol, R., Durkop, H., Melzig, M. F. & Fuchs, H. (2013) Targeted tumor therapy by epidermal growth factor appended toxin and purified saponin: an evaluation of toxicity and therapeutic potential in syngeneic tumor bearing mice, Molecular oncology. 7, 475-83.
Gilabert-Oriol, R., Thakur, M., Weise, C., Dernedde, J., von Mallinckrodt, B., Fuchs, H. & Weng, A. (2013) Small structural differences of targeted anti-tumor toxins result in strong variation of protein expression, Protein expression and purification. 91, 54-60.
Gilabert-Oriol, R., Thakur, M., von Mallinckrodt, B., Hug, T., Wiesner, B., Eichhorst, J., Melzig, M. F., Fuchs, H. & Weng, A. (2013) Modified trastuzumab and cetuximab mediate efficient toxin delivery while retaining antibody-dependent cell-mediated cytotoxicity in target cells, Molecular pharmaceutics. 10, 4347-57.
15. Gilabert-Oriol, R., Mergel, K., Thakur, M., von Mallinckrodt, B., Melzig, M. F., Fuchs, H. & Weng, A. (2013) Real-time analysis of membrane permeabilizing effects of oleanane saponins, Bioorganic & medicinal chemistry. 21, 2387-95.
(2012)
16. Weng, A., Thakur, M., von Mallinckrodt, B., Beceren-Braun, F., Gilabert-Oriol, R., Wiesner, B., Eichhorst, J., Bottger, S., Melzig, M. F. & Fuchs, H. (2012) Saponins modulate the intracellular trafficking of protein toxins, Journal of controlled release : official journal of the Controlled Release Society. 164, 74-86.
Weng, A., Thakur, M., Beceren-Braun, F., Bachran, D., Bachran, C., Riese, S. B., Jenett-Siems, K., Gilabert-Oriol, R., Melzig, M. F. & Fuchs, H. (2012) The toxin component of targeted anti-tumor toxins determines their efficacy increase by saponins, Molecular oncology. 6, 323-32.
Thakur, M., Mergel, K., Weng, A., Frech, S., Gilabert-Oriol, R., Bachran, D., Melzig, M. F. & Fuchs, H. (2012) Real time monitoring of the cell viability during treatment with tumor-targeted toxins and saponins using impedance measurement, Biosensors & bioelectronics. 35, 503-6.