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Dr. Daniel Bäcker

Pharmacist

DanielBäcker_01a_150

Freie Universität Berlin

Institut für Pharmazie

Pharmazeutische und Medizinische Chemie

Researcher

Address
Institut für Pharmazie
Königin-Luise-Straße 2+4
Room 125
14195 Berlin

05/23-dato: Wissenschaftlicher Mitarbeiter (PostDoc), Freie Universität Berlin (FU), Berlin, DE

08/22: Gastdozent, Hanoi University of Pharmacy (HUP), Hanoi, VNM

10/20-04/23: Wissenschaftlicher Mitarbeiter (PostDoc), Universität Greifswald (UG), Greifswald, DE

02/20-09/20: Wissenschaftlicher Mitarbeiter (PostDoc), Tiroler Krebsforschungsinstitut (TKFI), Medizinische Universität Innsbruck (MUI), Innsbruck, AT

01/20: Promotion zum Doctor of Philosophy (PhD), Pharmazeutische Wissenschaften

02/16-01/20: Wissenschaftlicher Mitarbeiter (PraeDoc), Leopold-Franzens-Universität (LFU), Innsbruck, AT

07/16: Allgemeine Berufsberechtigung als Apotheker, AT

12/15: Approbation als Apotheker, DE

05/15-11/15: Pharmazeut im Praktikum, Mohren-Apotheke zu St. Lorenz, Nürnberg, DE

11/14-04/15: Pharmazeut im Praktikum, University of Florida (UF), Gainesville, USA

10/10-07/14: Studium der Pharmazie, Friedrich-Alexander-Universität (FAU), Erlangen-Nürnberg, DE

[35] Dao Quang Tung, Do Thi Mai Dung, Nguyen Thanh Cong, Dao Ngoc Nam Hai, Daniel Baecker, Son Tung Ngo, Phan Thi Phuong Dung, Nguyen Thi Thuan, Nguyen Hai Nam, Nguyen Ngoc An*. Harmonizing QSAR Machine Learning-Based Models and Docking Approaches for Identifying Novel Histone Deacetylase 2 Inhibitors. Chemistry Select, 2024, 9(40), e202400404. https://doi.org/10.1002/slct.202400404

[34] David Krüger, Alexander Weng, Daniel Baecker*. Investigating the Discoloration of Leaves of Dioscorea polystachya Using Developed Atomic Absorption Spectrometry Methods for Manganese and Molybdenum. Molecules, 2024, 29(16): 3975. https://doi.org/10.3390/molecules29163975

[33] David Krüger, James T. P. Matshwele, Muhammad Dauda Mukhtar, Daniel Baecker*. Insights into the Versatility of Using Atomic Absorption Spectrometry in Antibacterial Research. Molecules, 2024, 29(13): 3120. https://doi.org/10.3390/molecules29133120

[32] Nguyen Duc Thien, Nguyen Hai-Nam, Duong Tien Anh*, Daniel Baecker*. Piezo1 and its inhibitors: Overview and perspectives. European Journal of Medicinal Chemistry, 2024, 273: 116502. https://doi.org/10.1016/j.ejmech.2024.116502

[31] Patricia Grabher, Paul Kapitza*, Nikolas Hörmann, Amelie Scherfler, Martin Hermann, Michael Zwerger, Hristo P. Varbanov, Brigitte Kircher, Daniel Baecker*, Ronald Gust*. Correction to “Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor-Positive Tumor Cells”. Journal of Medicinal Chemistry, 2024, 67(9): 7663. https://doi.org/10.1021/acs.jmedchem.4c00799

[30] Patricia Grabher, Paul Kapitza*, Nikolas Hörmann, Amelie Scherfler, Martin Hermann, Michael Zwerger, Hristo P. Varbanov, Brigitte Kircher, Daniel Baecker*, Ronald Gust*. Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor-Positive Tumor Cells. Journal of Medicinal Chemistry, 2024, 67(6): 4870-4888. https://doi.org/10.1021/acs.jmedchem.3c02454

[29] David Krüger, Alexander Weng*, Daniel Baecker*. Development and Application of an Atomic Absorption Spectrometry-Based Method to Quantify Magnesium in Leaves of Dioscorea polystachya. Molecules, 2024, 29(1), 109. https://doi.org/10.3390/molecules29010109

[28] Muhammad Dauda Mukhtar*, Fatihu Ahmad, Rufa’i, Abdurrahaman Umar Yola, Nafisa Ibrahim Babba, Daniel Baecker*. Evaluating the Potency of Selected Antibiotic Medications Dispensed in Community Pharmacies in Gwale, Kano, Nigeria. Antibiotics, 2023, 12(11), 1582. https://doi.org/10.3390/antibiotics12111582

 [27] Alexander Weninger, Jessica Sagasser, Victoria Obermoser, Josef Egger, Susanna Wisboeck, Qianqian Qui, Miriam Ladstaetter, Andrea Cucchiaro, Klaus Wurst, Daniel Baecker*, Ronald Gust*. Development of Zeise’s salt derivatives bearing substituted acetylsalicylic acid substructures as cytotoxic COX inhibitors. Pharmaceutics, 2023, 15(6), 1573. https://doi.org/10.3390/pharmaceutics15061573

[26] Le-Quang Bao, Daniel Baecker, Do Thi Mai Dung, Nguyen Phuong Nhung, Nguyen Thi Thuan, Phuong Linh Nguyen, Phan Thi Phuong Dung, Tran Thi Lan Huong, Bakhtiyor Rasulev, Gerardo M. Casanola-Martin, Nguyen-Hai Nam*, Hai Pham-The*. Development of activity rules and chemical fragment design for in silico discovery of AChE and BACE1 dual inhibitors against Alzheimer’s disease. Molecules, 2023, 28(8), 3588. https://doi.org/10.3390/molecules28083588

[25] Fatihu Ahmad Rufa’i, Daniel Baecker, Muhammad Dauda Mukhtar*. Phytochemical screening, GC-MS analysis, and evaluating in vivo antitrypanosomal effects of a methanolic extract of Garcinia kola nuts on rats. Antibiotics, 2023, 12(4), 713. https://doi.org/10.3390/antibiotics12040713

[24] Duong Tien Anh, Nguyen Hai Nam, Brigitte Kircher*, Daniel Baecker*. The impact of fluorination on the design of histone deacetylase inhibitors. Molecules, 2023, 28(4), 1973. https://doi.org/10.3390/molecules28041973

[23] Frieda-Marie Bartz, Kristin Beirow, Konrad Wurm, Daniel Baecker, Andreas Link, Patrick J. Bednarski*. A graphite furnace-atomic absorption spectrometry-based rubidium efflux assay for screening activators of the Kv7.2/3 channel. Archiv der Pharmazie, 2023, 356(5), 2200585. https://doi.org/10.1002/ardp.202200585

[22] Benjamin N. Ma, Daniel Baecker, Hubert Descher, Philipp Brandstaetter, Martin Hermann, Brigitte Kircher*, Ronald Gust*. Synthesis and biological evaluation of salophen nickel(II) and cobalt(III) complexes as potential anticancer compounds. Archiv der Pharmazie, 2023, 356(5), 2200655. https://doi.org/10.1002/ardp.202200655

[21] Daniel Baecker*, Do Thi Mai Dung, Hai Pham-The, Nguyen Hai-Nam. Comparison of the university pharmacy education programs in Germany and Vietnam. Pharmacy, 2022, 10(6), 146. https://doi.org/10.3390/pharmacy10060146

[20] Elias Eger, Michael Schwabe, Lukas Schulig, Nils-Olaf Hübner, Jürgen A. Bohnert, Uwe T. Bornscheuer, Stefan E. Heiden, Justus U. Müller, Fazal Adnan, Karsten Becker, Carlos Correa-Martinez, Sebastian Guenther, Evgeny A. Idelevich, Daniel Baecker, Katharina Schaufler*. Extensively drug-resistant Klebsiella pneumoniae Counteracts fitness and virulence costs that accompanied Ceftazidime-Avibactam resistance acquisition. Microbiology Spectrum, 2022, 10(3), e0014822. https://doi.org/10.1128/spectrum.00148-22

[19] Daniel Baecker*. Introducing audio podcasts into a practical laboratory course for pharmacy students as a novel tool of performance assessment. Pharmacy, 2022, 10(2), 40. https://doi.org/10.3390/pharmacy10020040

[18] Daniel Baecker*, Sebastian Guenther. General applicability of high-resolution continuum-source graphite furnace molecular absorption spectrometry to the quantification of oligopeptides using the example of glutathione. Analytica, 2022, 3(1), 24-35. https://doi.org/10.3390/analytica3010003 

[17] Steven Behnisch-Cornwell, Christoph W. Grathwol, Lukas Schulig, Anika Voigt, Daniel Baecker, Andreas Link, Patrick J. Bednarski*. Correlation analysis of protein expression of 10 HDAC/sirtuin isoenzymes with sensitivities of 23 anticancer drugs in 17 cancer cell lines and potentiation of drug activity by co-treatment with HDAC inhibitors. Cancers, 2022, 14(1), 187. https://doi.org/10.3390/cancers14010187

[16] Daniel Baecker, Jessica Sagasser, Serhat Karaman, Anton A. Hörmann, Ronald Gust*. Development of methylated cobalt alkyne complexes with selective cytotoxicity against COX-positive cancer cell lines. Archiv der Pharmazie, 2021, 355(2): e2100408. https://doi.org/10.1002/ardp.202100408

[15] Lisa Wolff, Siva S. M. Bandaru, Elias Eger, Hoai-Nhi Lam, Martin Napierkowski, Daniel Baecker, Carola Schulzke*, Patrick J. Bednarski*. Comprehensive evaluation of biological effects of pentathiepins on various human cancer cell lines and insights into their mode of action. International Journal of Molecular Sciences, 2021, 22(14): 7631. https://doi.org/10.3390/ijms22147631

[14] Caroline M.Gallati, Sina K. Goetzfried, Anna Ortmeier, Jessica Sagasser, Klaus Wurst, Martin Hermann, Daniel Baecker, Brigitte Kircher, Ronald Gust*. Synthesis, characterization and biological activity of bis[3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1,3-dihydro-2H-imidazol-2-ylidene]gold(I) complexes. Dalton Transactions, 2021, 50(12): 4270-4279. https://doi.org/10.1039/D0DT03902K

[13] Daniel Baecker, Özcan Sesli, Ludwig Knabl, Silke Huber, Dorothea Orth-Höller, Ronald Gust*. Investigating the antibacterial activity of salene/salophene metal complexes: Induction of ferroptosis as part of the mode of action. European Journal of Medicinal Chemistry, 2021, 209: 112907. https://doi.org/10.1016/j.ejmech.2020.112907

[12] Daniel Baecker, Timo Kapp, Petra Schumacher, Ronald Gust, Brigitte Kircher*. Cell death-inducing properties of selected dendrimers against different breast cancer and leukemia cell lines. Archiv der Pharmazie, 2020, 353(11): e2000209. https://doi.org/10.1002/ardp.202000209

[11] Daniel Baecker, Benjamin N. Ma, Jessica Sagasser, Lukas Schultz, Carina Hörschläger, Maria Weinreich, Lucy Steiner, Brigitte Kircher, Ronald Gust*. Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(III) as necroptosis and ferroptosis inducers. Dalton Transactions, 2020, 49(20): 6842-6853. https://doi.org/10.1039/D0DT00168F

[10] Caroline M. Gallati, Sina K. Goetzfried, Marjana Ausserer, Jessica Sagasser, Matthias Plangger, Klaus Wurst, Martin Hermann, Daniel Baecker, Brigitte Kircher, Ronald Gust*. Synthesis, characterization and biological activity of bromido[3-ethyl-4-aryl-5-(2-methoxypyridin-5-yl)-1-propyl-1,3-dihydro-2H-imidazol-2-ylidene]gold(I) complexes. Dalton Transactions, 2020, 49(17): 5471-5481. https://doi.org/10.1039/C9DT04824C

[9] Julian D. Wolf, Markus Kurpiers, Roman X. Götz, Sergey Zaichik, Andrea Hupfauf, Daniel Baecker, Ronald Gust, Andreas Bernkop-Schnürch*. Phosphorylated PEG-emulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery systems (SEDDS). European Journal of Pharmaceutics and Biopharmaceutics, 2020, 150: 77-86. https://doi.org/10.1016/j.ejpb.2020.03.004

[8] Alexandra Knox, Christina Kalchschmid, Daniela Schuster, Francesca Gaggia, Claudia Manzl, Daniel Baecker, Ronald Gust*. Development of bivalent triarylalkene- and cyclofenil-derived dual estrogen receptor antagonists and downregulators. European Journal of Medicinal Chemistry, 2020, 192: 112191. https://doi.org/10.1016/j.ejmech.2020.112191

[7] Daniel Baecker, Victoria Obermoser, Elisabeth A. Kirchner, Andrea Hupfauf, Brigitte Kircher, Ronald Gust*. Fluorination as tool to improve sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes. Dalton Transactions, 2019, 48(42): 15856-15868. https://doi.org/10.1039/C9DT03330K

[6] Jessica Sagasser, Benjamin N. Ma, Daniel Baecker, Stefan Salcher, Martin Hermann, Julia Lamprecht, Stefanie Angerer, Petra Obexer, Brigitte Kircher, Ronald Gust*. A new approach in cancer treatment: Discovery of chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) complexes as ferroptosis inducers. Journal of Medicinal Chemistry, 2019, 62(17): 8053-8061. https://doi.org/10.1021/acs.jmedchem.9b00814

[5] Sami El Deeb, Benjamin N. Ma, Daniel Baecker, Ronald Gust*. Studies on the stability of the anticancer-active [N,N‘-bis(salicylidene)-1,2-phenylenediamine]chloridoiron(III) complex under pharmacological-like conditions. Inorganica Chimica Acta, 2019, 487: 76-80. https://doi.org/10.1016/j.ica.2018.12.002

[4] Christina Leichner, Christian Steinbring, Randi A. Baus, Daniel Baecker, Ronald Gust, Andreas Bernkop-Schnürch*. Reactive keratin derivatives: A promising strategy for covalent binding to hair. Journal of Colloid and Interface Science, 2019, 534: 533-541. https://doi.org/10.1016/j.jcis.2018.09.062

[3] Max Jelkmann, Claudia Menzel, Randi A. Baus, Philipp Ausserhofer, Daniel Baecker, Ronald Gust, Andreas Bernkop-Schnürch*. Chitosan: The one and only? Aminated cellulose as an innovative option for primary amino groups containing polymers. Biomacromolecules, 2018, 19(10): 4059-4067. 
https://doi.org/10.1021/acs.biomac.8b01069

[2] Alexander Weninger, Daniel Baecker, Victoria Obermoser, Dorothea Egger, Klaus Wurst, Ronald Gust*. Synthesis and biological evaluation of Zeise’s salt derivatives with acetylsalicylic acid substructure. International Journal of Molecular Sciences, 2018, 19(6): 1612. https://doi.org/10.3390/ijms19061612

[1] Victoria Obermoser, Daniel Baecker, Carina Schuster, Valentin Braun, Brigitte Kircher, Ronald Gust*. Chlorinated cobalt alkyne complexes derived from acetylsalicylic acid as new specific antitumor agents. Dalton Transactions, 2018, 47(12): 4341-4351. https://doi.org/10.1039/C7DT04790H