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Pregnancy and its impact on Pharmacokinetics of Monoclonal Antibodies - Literature review [Pregnancy]

Monoclonal antibodies (mAb) revolutionised the treatment of immune-mediated inflammatory diseases (IMIDs) such as inflammatory bowel disease (IBD) or rheumatoid arthritis (RA) where remission finally became achievable. Even though these diseases affect more women than men and are diagnosed during reproductive age, little is known about the pharmacokinetics (PK) of these drugs in pregnancy. The students will perform a literature review on the physiological changes happening in pregnancy and its impact on the pharmacokinetics of mAb. The placental transfer of both endogenous immunoglobulins G (IgG) and mAb will also be explored.

Further Information: Pregnancy

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Aktueller Bewerbungsschluss: verlängert bis 2024-11-29